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Stock impact report

Cognition Therapeutics: Approaching Phase 2 Readout In Alzheimer's [Seeking Alpha]

Cognition Therapeutics, Inc. (CGTX) 
Company Research Source: Seeking Alpha
CT1812, the company's lead drug candidate, is a sigma-2 receptor antagonist for Alzheimer's and aims to prevent the binding of toxic Aß oligomers. Preliminary data from the ongoing SHINE trial showed some interesting results, but were not consistent with other previous studies, raising caution about the upcoming data. At a ~$70 million market cap with about half of that cash, the topline readout could be a binary event for the stock. Thesis Cognition Therapeutics ( NASDAQ: CGTX ) should report topline data of its Phase 2 trial in Alzheimer's disease in mid-2024. CGTX's CT1812 is an oral s-2 receptor antagonist that prevents binding of toxic Aß oligomers, which mimics the neuroprotective benefit of a genetic mutation found in Iceland. That idea, like many others in Alzheimer's, is interesting, but not groundbreaking. Insofar as I know, CT1812 is the only sigma-2 receptor antagonist for Alzheimer's. Though preliminary data of the ongoing SHINE trial looked interesting, they Show less Read more
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