Conatus Pharmaceuticals Announces Publication Demonstrating that Emricasan Ameliorates Portal Hypertension, Improves Liver Structure and Function in a Preclinical Model of Advanced Cirrhos...
CONATUS PHARMACEUTICALS INC (CNAT)
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Source: GlobeNewswire
SAN DIEGO, April 30, 2019 (GLOBE NEWSWIRE) -- Conatus Pharmaceuticals Inc. (Nasdaq:CNAT) today announced a new publication1 in Hepatology Communications detailing results following seven-day treatment with emricasan, the company’s first-in-class pan-caspase inhibitor, in rats with advanced cirrhosis including increased portal pressure induced by chronic carbon tetrachloride administration. Portal pressure was significantly reduced in emricasan-treated rats relative to vehicle-treated control animals. Reduced portal pressure was associated with significantly better liver function, reduced liver inflammation, and reduced fibrosis. Improvements in expression of markers of liver function, including increased expression of vasodilators and reduced expression of vasoconstrictors, were observed in liver cells isolated from emricasan-treated cirrhotic rats. In vitro experiments treating human cirrhotic liver cells with emricasan improved the synthetic capacity of hepatocytes from cirrhotic
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