Histogen Publishes New Preclinical Data on its HST 003 Orthopedic Program
CONATUS PHARMACEUTICALS INC (CNAT)
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Source: GlobeNewswire
SAN DIEGO, April 15, 2020 (GLOBE NEWSWIRE) -- Histogen Inc., a regenerative medicine company with a novel biological platform that replaces and regenerates tissues in the body, announced today the publication of data on its human extracellular matrix (hECM) for cartilage regeneration in the Journal of Orthopaedic and Trauma Care. Histogen has developed a patented embryonic-like hECM that contains components associated with stem cell niches in the body and scar-less healing of fetal skin including laminins, osteonectin, decorin, hyaluronic acid, collagen type IV, SPARC, CXCL12, NID1, NID2, NOTCH2, tenascin, thrombospondin, fibronectin, versican, and fibrillin-2. In vitro studies have demonstrated that HST 003 induces the proliferation of human mesenchymal stem cells (hMSCs) while retaining their stemness and causing them to down regulate collagen 1 and up regulate aggrecan, both important characteristics of forming hyaline cartilage. “We have now tested HST 003 in three animal mode
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