Centessa Pharmaceuticals Announces Open IND for ORX750; Proof-of-Concept Data in Sleep-Deprived Healthy Volunteers Planned for 2H 2024 [Yahoo! Finance]
Centessa Pharmaceuticals plc - American Depositary Shares (CNTA)
Company Research
Source: Yahoo! Finance
to discover and develop medicines that are transformational for patients, today announced that the U.S. Food and Drug Administration (FDA) has cleared the Investigational New Drug application (IND) to initiate a Phase 1 first-in-human, clinical trial of ORX750 for the treatment of narcolepsy. ORX750 is an investigational, orally administered, highly potent and selective orexin receptor 2 (OX2R) agonist designed to directly target the underlying pathophysiology of orexin neuron loss in narcolepsy type 1 (NT1), with potential applicability to narcolepsy type 2 (NT2), idiopathic hypersomnia (IH), and other sleep-wake disorders with normal orexin levels. The Phase 1 study will evaluate the safety, tolerability and pharmacokinetics of single-ascending doses (SAD) and multiple-ascending doses (MAD) of ORX750 in healthy adult subjects. In parallel to the SAD, a cross-over pharmacodynamic (PD) assessment will be performed utilizing the Maintenance of Wakefulness Test (MWT) and Karolinska Sl
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News
- Iktos announces the appointment of Roman Fleck as Chairman of the Board [Yahoo! Finance]Yahoo! Finance
- Iktos announces the appointment of Roman Fleck as Chairman of the Board GlobeNewswire
- Centessa: Hemophilia B Data Readout In 2024 Is Major Turning Point [Seeking Alpha]Seeking Alpha
- Centessa Pharmaceuticals Announces Pricing of $100 Million Public Offering of American Depositary Shares [Yahoo! Finance]Yahoo! Finance
- Centessa Pharmaceuticals Announces Pricing of $100 Million Public Offering of American Depositary SharesGlobeNewswire
CNTA
Earnings
- 11/13/23 - Beat
CNTA
Sec Filings
- 4/26/24 - Form PRE
- 4/25/24 - Form 424B5
- 4/24/24 - Form 8-K
- CNTA's page on the SEC website