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Stock impact report

Crinetics (CRNX) Up as Second Acromegaly Study Meets Goals [Yahoo! Finance]

Crinetics Pharmaceuticals, Inc. (CRNX) 
Last crinetics pharmaceuticals, inc. earnings: 3/9 04:10 pm Check Earnings Report
Company Research Source: Yahoo! Finance
late-stage studies evaluating the efficacy and safety of lead candidate, paltusotine, for the treatment of acromegaly. Acromegaly is a rare endocrine disease generally caused by a pituitary adenoma, which is a non-cancerous tumor in the pituitary that secretes growth hormone. The PATHFNDR-2 study is evaluating paltusotine, an oral SST2 agonist, in participants with acromegaly who are treatment-naïve or not currently receiving medical therapy. Per the data readout, the phase III PATHFNDR-2 study met its primary endpoint, with statistical significance, observing that 56% of patients treated with paltusotine achieved an insulin-like growth factor 1 (IGF-1) level = 1.0 times the upper limit of normal (xULN) compared with those who received placebo (5%). Crinetics also reported that all secondary endpoints met statistical significance. Additionally, CRNX stated that the candidate was overall well tolerated with no serious adverse events in the PATHFNDR-2 study. Management believe Show less Read more
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