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0.000213492741246806 0.000853970964987223 0.00291773413037288 0.00170794192997445 0.00668943922573298 -0.000711642470822618 0.00483916880159413 0.00483916880159413
Stock impact report

CRISPR (CRSP) to Focus on Next-Generation CAR T Pipeline [Yahoo! Finance]

CRISPR Therapeutics AG - Common Shares (CRSP) 
Last crispr therapeutics ag - common shares earnings: 8/7 05:01 pm Check Earnings Report
US:NASDAQ Investor Relations: nasdaq.com/symbol/crsp/real-time
Company Research Source: Yahoo! Finance
CRSP announced its decision to discontinue the development of first-generation allogeneic CAR T product candidates, CTX110 (targeting CD19) and CTX130 (targeting CD70). Management will focus on developing their respective next-generation CAR T candidates, CTX112 and CTX131. As part of this decision, it will transition patients treated with first-generation candidates to long-term follow-up programs where needed. This decision is based on preliminary data from ongoing early-stage clinical studies, which suggest that CTX112 and CTX131 have the potential to improve upon the clinical profile observed with CTX110 and CTX130, respectively. Per management, the gene-edits made for next-generation candidates lead to significantly higher CAR T cell expansion and functional persistence in patients compared with the first-generation candidates. Also, CTX112 and CTX131 have demonstrated increased manufacturing robustness, with a higher and more consistent number of CAR T cells produced per ba Show less Read more
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