ContraVir Pharmaceuticals Sets the Stage for CRV431 Development in NASH with Positive Results from Second Model of Liver Fibrosis
CONTRAVIR PHARMACEUTICALS INC (CTRV)
US:NASDAQ Investor Relations:
ir.contravir.com/investor-relations
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Source: GlobeNewswire
EDISON, N.J., June 06, 2019 (GLOBE NEWSWIRE) -- ContraVir Pharmaceuticals, Inc. (NASDAQ:CTRV), a biopharmaceutical company focused on the development of therapeutic drugs for the treatment of liver disease arising from non-alcoholic steatohepatitis (“NASH”) and chronic viral infection, today announced findings from a preclinical study where CRV431, a novel cyclophilin inhibitor, significantly decreased the extent of fibrosis in a second animal model of liver fibrosis. Fibrosis, or scarring, of the liver is a hallmark symptom of NASH that results in impaired liver function. Obeticholic acid (“OCA”), a semi-synthetic bile acid analogue drug approved for the treatment primary biliary cholangitis (“PBC”) and being evaluated in Phase 3 trials by another company, was used as a comparator drug in the study and did not decrease the extent of fibrosis in this study conducted by ContraVir. In this industry-standard model, liver fibrosis is induced in mice by administering carbon tetrac
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