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Stock impact report

DiaMedica (DMAC) Up as Stroke Study Dosing Begins Post Relaunch [Yahoo! Finance]

DiaMedica Therapeutics Inc. (DMAC) 
Last diamedica therapeutics inc. earnings: 11/13 04:12 pm Check Earnings Report
Company Research Source: Yahoo! Finance
the safety and efficacy of its lead product candidate, DM199, to treat acute ischemic stroke (AIS). The company's shares gained 9.7% on Apr 17, following the encouraging news. DM199 is DiaMedica's recombinant (synthetic) form of human tissue kallikrein-1, which will be developed in the pivotal phase II/III ReMEDy2 study for AIS patients. The investigational candidate's novel mechanism of action aims at enhancing collateral blood flow in the brain tissues affected by the stroke. In 2022, the FDA placed a clinical hold on DiaMedica's ReMEDy2 study of DM199 based on three reports of serious treatment-related adverse events. It was observed that those three AIS patients experienced clinically significant transient hypotension (low blood pressure), shortly after initiation of the intravenous (IV) dose of DM199. Additionally, the blood pressure levels of the three patients recovered back to their baseline blood pressure within minutes after the IV infusion was stopped. Eventually, t Show less Read more
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