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-0.011015911872705 -0.00979192166462669 -0.00979192166462669 -0.011015911872705 -0.00244798041615662 0.0127050183598533 0.0134638922888618 0.00856793145654838
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Editas Medicine Reports In Vivo Proof-of-Concept Data for EDIT-401 at the European Society of Gene and Cell Therapy (ESGCT) 32nd Annual Congress

Editas Medicine, Inc. (EDIT) 
Last editas medicine, inc. earnings: 2/26 04:02 pm Check Earnings Report
US:NASDAQ Investor Relations: ir.editasmedicine.com
Company Research Source: GlobeNewswire
CAMBRIDGE, Mass., Oct. 09, 2025 (GLOBE NEWSWIRE) -- Editas Medicine, Inc. (Nasdaq: EDIT), a pioneering gene editing company, today reported in vivo preclinical proof-of-concept data for EDIT-401, an experimental, potential best-in-class, one-time therapy to significantly reduce LDL-cholesterol (LDL-C), at the 32nd Annual European Society of Gene and Cell Therapy (ESGCT) Congress in Seville, Spain. The Company shared results from preclinical studies demonstrating potent and durable reductions in LDL-C through upregulation of the LDL receptor (LDLR). Key EDIT-401 Data Presented includes: Robust efficacy data: =90% LDL-C reduction in non-human primates achieved within 48 hours of a single dose of EDIT-401; =90% LDL-C reduction in mice with high baseline LDL-C and reduced LDLR functionOptimized therapeutic strategy: CRISPR/Cas9 nuclease and dual gRNAs with LNP delivery disrupt negative regulatory elements in the 3' UTR, increasing mRNA stability enabling potent LDLR upregulation=6-fol Show less Read more
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