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0.151394422310757 0.470119521912351 0.147410358565737 0.00378486055776895 0 0.0517928286852589 -0.043784860557769 -0.0478087649402391
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Enveric Biosciences Reports EB-003 BRET Receptor Engagement Assay Data

Enveric Biosciences, Inc. (ENVB) 
Company Research Source: Business Wire
Proprietary assays demonstrate dual Gq and ß-arrestin signaling at 5-HT2A, pathways linked in peer-reviewed studies to antidepressant and anxiolytic effectsA recent independent Nature study reports that distinct signaling pathways support mechanistic separation of therapeutic benefit from hallucinations CAMBRIDGE, Mass.--(BUSINESS WIRE)--Enveric Biosciences (NASDAQ: ENVB) (“Enveric” or the “Company”), a biotechnology company advancing novel neuroplastogenic small-molecule therapeutics to address psychiatric and neurological disorders, today announced new mechanistic data demonstrating that its lead candidate, EB-003, activates both Gq- and ß-arrestin–mediated signaling downstream of the 5-HT2A receptor. Multiple independent, peer-reviewed studies have previously shown that selective activation of 5-HT2A receptor, by either Gq-biased or ß-arrestin–biased agonists, can independently produce antidepressant- and anxiolytic-like effects in preclinical models, suggesting that therapeutic Show less Read more
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