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Eupraxia Pharmaceuticals Reports Six-Month Symptom Data from the Highest Dose Cohort in its Ongoing Phase 1b/2a RESOLVE Trial in Eosinophilic Esophagitis [Yahoo! Finance]

Eupraxia Pharmaceuticals Inc. (EPRX) 
Company Research Source: Yahoo! Finance
The data is important because it is from one of the two doses that are being studied in the placebo-controlled Phase 2b portion of the study. Patients in the highest dose cohort (n=3) had an average reduction of 4 points in their symptom scores compared to baseline (as measured by SDI, where a 3 point reduction is clinical remission). Across dose cohorts 4-9, the decrease in symptom response is the highest at 24 weeks, compared to earlier timepoints. This underlines the value of continuous and steady steroid exposure to reduce inflammation early and fibrosis over time in EoE patients. EP-104GI continues to be well tolerated by patients receiving the drug; 31 patients have been treated in the Phase1b/2a study and over 220 patient-months of follow-up have been reported with no Serious Adverse Events ("SAEs"). There have been no cases of oropharyngeal candidiasis, a commonly reported adverse event with the oral delivery of steroids. VICTORIA, British Columbia, March 17, 2026 (GLO Show less Read more
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