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Stock impact report

Fate Therapeutics Details FT819 CAR T Manufacturing and Phase II Lupus Trial Plans at Conference [Yahoo! Finance]

Fate Therapeutics, Inc. (FATE) 
Last fate therapeutics, inc. earnings: 3/2 04:01 pm Check Earnings Report
US:NASDAQ Investor Relations: ir.fatetherapeutics.com/investor-relations
Company Research Source: Yahoo! Finance
FT819 manufacturing: Fate uses a clonal master cell bank approach for its off-the-shelf CD8 CAR T, claiming a single bank could yield 10 million doses and the current facility could produce ~50,000 doses by increasing staffing, with cost of goods ~ $3,000 per dose at 100-liter scale. Clinical strategy and lupus focus: FT819 was engineered with reduced signaling (mutated CD3? ITAMs) to prioritize safety—reported no ICANS or GVHD and low-grade CRS—and, after modest durability in high-burden DLBCL (~40% CR), Fate is advancing a potential registration-enabling Phase II single-arm trial in lupus nephritis in 2H while already observing meaningful outpatient-administered patient improvements. Next-generation programs: Fate is developing multiplex-edited candidates (notably FT839 ) in a "Sword and Shield" strategy designed to eliminate conditioning and broaden activity by targeting CD19 and CD38 with intact CD3? for greater potency. Interested in Fate Therapeutics, Inc.? Here are five Show less Read more
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