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Fulcrum Therapeutics Touts PIONEER HbF Gains, Early VOC Signal; FDA Path and Accelerated Approval Talk [Yahoo! Finance]

Fulcrum Therapeutics, Inc. (FULC) 
Last fulcrum therapeutics, inc. earnings: 3/5 07:00 am Check Earnings Report
Company Research Source: Yahoo! Finance
7.1% to 19.3% over 12 weeks, ?12.2), improvement in hemolysis markers, and an early vaso-occlusive crisis (VOC) reduction signal (6 VOCs observed vs. 16 expected; 7 of 12 patients had no VOC during treatment). Regulatory path : Fulcrum plans an FDA end-of-phase meeting in Q2 and intends to start a 200–300 patient registrational trial in H2, with a planned interim 6-month HbF analysis in ~half the cohort to support a potential accelerated approval. Safety, focus and funding : Hematologic safety signals include decreased reticulocytes and increased total hemoglobin with no broad cytopenias aside from one parvovirus-related case; the company is refocusing on sickle cell, has discontinued its DBA program, and reports cash runway into 2029 with U.S. commercialization preferred and likely ex-U.S. partnerships. Interested in Fulcrum Therapeutics, Inc.? Here are five stocks we like better. Fulcrum Therapeutics (NASDAQ:FULC) executives highlighted what they described as strong physicia Show less Read more
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