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Positive topline results with GLPG1972 in osteoarthritis patients

Galapagos NV ADS (GLPG)  More Company Research Source: GlobeNewswire
Last galapagos nv ads earnings: 4/25 04:01 pm Check Earnings Report
US:NASDAQ Investor Relations: glpg.com/company-overview
PDF Mechelen, Belgium; 7 January 2018, 22.00 CET - Galapagos NV (Euronext & NASDAQ: GLPG) reports positive preliminary topline results with a Phase 1b study in osteoarthritis (OA) patients in the United States. Galapagos evaluated GLPG1972 in a randomized, placebo-controlled, double-blind Phase 1b study in 30 patients aged 50 to 75 years with diagnosis of knee and/or hip osteoarthritis, in the United States. Patients were given one of three doses of GLPG1972 or placebo for a total of 4 weeks, with a 3 week follow-up period. Primary objectives were to evaluate safety, tolerability, and pharmacokinetics of GLPG1972 in patients. A secondary objective was to measure the reduction of ARGS neoepitope, an important cartilage breakdown biomarker. The mechanism of action of GLPG1972, which targets a cartilage degrading enzyme called ADAMTS-5, was confirmed in two animal models. An earlier Phase 1 study in healthy volunteers met all its safety and pharmacokinetic targets and also demons [Read more]

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