Genfit And GenKyoTex In PBC: What To Expect In Phase 3 [Seeking Alpha]
GENFIT S.A. - American Depositary Shares (GNFT)
Company Research
Source: Seeking Alpha
Genfit And GenKyoTex In PBC: What To Expect In Phase 3 Summary Genfit and GenKyoTex are both small market-cap biopharmas with a different but unique therapeutic approach to Cholestatic Liver Disease, PBC. Elafibranor developed by Genfit was associated with a significant decrease in levels of the cholestatic biomarker, alkaline phosphatase, in PBC patients at 12 weeks without worsening of pruritus. Similarly, Setanaxib, a selective dual NOX1/4 inhibitor in clinical development for PBC by GenKyoTex, was associated with anti-fibrotic and anti-cholestasis benefits at 24 weeks with no safety signals. Both companies have each reported plans for a Phase 3 PBC study for their respective drug candidates. I provide an overview on what I would expect from these planned studies. Introduction For two decades, the scientific advance of investigative drug candidates for PBC into clinical development seemed like an illusion. FDA approval of obeticholic acid (i.e. ocaliva) in 2016 as a breakthrough th
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- GENFIT: Publication of the 2024 Extra-Financial Performance Report (fiscal year 2023) [Yahoo! Finance]Yahoo! Finance
- GENFIT: Publication of the 2024 Extra-Financial Performance Report (fiscal year 2023)GlobeNewswire
- GENFIT Annual Combined General Meeting of May 22, 2024 — Availability of Preparatory Documents [Yahoo! Finance]Yahoo! Finance
- GENFIT Annual Combined General Meeting of May 22, 2024 — Availability of Preparatory DocumentsGlobeNewswire
- GENFIT Announces Publication of the 2023 Universal Registration Document and the 2023 Annual Report on Form 20-F [Yahoo! Finance]Yahoo! Finance