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0 0.0283755475147591 0.0251380689392496 -0.0382784231574938 -0.113406970100933 -0.185107598552657 -0.285706532089126 -0.376261664444868
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Werewolf Therapeutics Announces Pipeline and Business Updates

Werewolf Therapeutics, Inc. (HOWL) 
Company Research Source: GlobeNewswire
WTX-124 initial Phase 1b expansion arm data showed 30% overall response rate as a monotherapy in a defined subset of post-ICI advanced or metastatic cutaneous melanoma patients, with potential best-in-class tolerability profileWTX-330 Phase 1b/2 trial initial data demonstrated additional evidence of antitumor activity and highly favorable tolerability profile, building upon monotherapy activity demonstrated in first-in-human Phase 1 clinical trialAdditional Phase 1/1b data update for WTX-124 and completion of Part A of Phase 1b/2 clinical trial for WTX-330 are both expected in the first half of 2026WTX-1011, Werewolf’s first nominated INDUCER™ T cell engager development candidate targeting advanced, relapsed/refractory STEAP1-expressing cancers, continues to progress towards IND; with the announcement of Werewolf’s second INDUCER development candidate, WTX-2022, targeting CDH6-expressing cancers, Werewolf is now planning for two INDs by mid-2027 WATERTOWN, Mass., Dec. 18, 2025 (GLO Show less Read more
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