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ImmunityBio (IBRX) Announces NCCN Update Clinical Practice Guidelines to Include ANKTIVA for Papillary-Only NMIBC [Yahoo! Finance]

ImmunityBio, Inc. (IBRX) 
Company Research Source: Yahoo! Finance
announced that the National Comprehensive Cancer Network/NCCN updated its 2026 Clinical Practice Guidelines to include ANKTIVA (nogapendekin alfa inbakicept-pmln) in combination with Bacillus Calmette-Guérin/BCG. This update adds a recommendation for patients with BCG-unresponsive non-muscle invasive bladder cancer/NMIBC who have papillary-only disease. Previously, the guidelines recognized the combination only for patients with carcinoma in situ/CIS, but this expansion acknowledges the regimen's long-term effectiveness and safety for a broader patient population. The treatment is a first-in-class IL-15 receptor agonist designed to activate the body's natural killer cells and T cells to target cancer. By mimicking natural biological properties, the therapy aims to overcome tumor resistance and establish immune memory, leading to more durable responses. While the NCCN's inclusion of papillary-only disease is a Category 2A recommendation, the company noted that this specific use is no Show less Read more
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