Melodia Therapeutics Announces U.S. Patent Grant Covering MLD-151 [Yahoo! Finance]
Insmed Incorporated (INSM)
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Source: Yahoo! Finance
granted a key U.S. patent covering a structurally novel DPP1 (Cathepsin C) inhibitor, currently developed as MLD-151 by Melodia Therapeutics and discovered by its partner, Alivexis, Inc., strengthening the intellectual property foundation supporting Melodia's lead development program. Melodia Therapeutics AG logo (PRNewsfoto/Melodia Therapeutics AG) The newly issued patent (U.S. Patent No. 12,522,593; International Application No. PCT/JP2023/021735), entitled "Azacycloalkyl Carbonyl Cyclic Amine Compound," is held by Alivexis, Inc. and Astellas Pharma Inc. and covers a proprietary compound series that Melodia licensed in June 2024 exclusively and on a global basis to develop, manufacture, and commercialize the program. MLD-151 is based on a structurally distinct chemotype that is clearly differentiated from earlier DPP1 inhibitors built on dipeptidyl nitrile scaffolds. MLD-151 and this novel chemotype was designed to enable differentiated pharmacology, including the potential fo
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