IO Biotech Presents Phase 3 Results for Cylembio® plus KEYTRUDA® (pembrolizumab) in First-line Advanced Melanoma at ESMO 2025
IO Biotech, Inc. (IOBT)
Company Research
Source: GlobeNewswire
Cylembio plus pembrolizumab achieved a clinically relevant 19.4 months median progression free survival (mPFS) compared to 11.0 months mPFS with pembrolizumab alone; study narrowly missed progression free survival (PFS) primary endpoint for statistical significance Improvement in PFS favored the combination across virtually all subgroups, notably in patients with PD-L1-negative tumors, BRAFV600-mutated tumors, and elevated LDH, without adding any systemic toxicity compared to pembrolizumab alone Final data from the Phase 2 basket trial in lung and head & neck cancers also presented NEW YORK, Oct. 20, 2025 (GLOBE NEWSWIRE) -- IO Biotech (Nasdaq: IOBT), a clinical-stage biopharmaceutical company developing novel, immune-modulatory, off-the-shelf therapeutic cancer vaccines, today presented detailed results from its global Phase 3 trial (IOB-013/KN-D18) of Cylembio® (imsapepimut and etimupepimut, adjuvanted), in combination with Merck’s (known as MSD outside the United States and Cana
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News
- IO Biotech Announces Participation in Upcoming December Investor Conferences [Yahoo! Finance]Yahoo! Finance
- IO Biotech Announces Participation in Upcoming December Investor ConferencesGlobeNewswire
- IO Biotech (NASDAQ:IOBT) was upgraded by analysts at <a style="font-weight:bold" href="https://www.wallstreetzen.com/newsletters/zen-ratings?ticker=IOBT&utm_campaign=getratings&utm_medium=online&utm_source=MarketBeat">Wall Street Zen</a>MarketBeat
- IO Biotech, Inc. (IOBT) Upgraded to Buy: Here's Why [Yahoo! Finance]Yahoo! Finance
- IO Biotech GAAP EPS of -$0.13 beats by $0.25 [Seeking Alpha]Seeking Alpha
IOBT
Sec Filings
- 11/21/25 - Form 8-K
- 11/18/25 - Form 8-K
- 11/14/25 - Form SCHEDULE
- IOBT's page on the SEC website