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Opus Genetics Announces Dosing of First Participant in OPGx-BEST1 Phase 1/2 Gene Therapy Clinical Trial for Best Disease [Yahoo! Finance]

Opus Genetics, Inc. (IRD) 
Company Research Source: Yahoo! Finance
Initial data expected in Q1 2026 RESEARCH TRIANGLE PARK, N.C., Nov. 13, 2025 (GLOBE NEWSWIRE) -- Opus Genetics , (Nasdaq: IRD) (the “Company” or “Opus Genetics”), a clinical-stage biopharmaceutical company developing gene therapies to restore vision and prevent blindness in patients with inherited retinal diseases (IRDs), today announced that the first participant has been dosed in the Company's OPGx-BEST1 Phase 1/2 clinical trial for Best disease (BEST1). Best disease, or vitelliform macular dystrophy, is a rare, inherited retinal condition causing macular degeneration by mutations in the BEST1 gene, leading to progressive vision loss and, in some cases, blindness. OPGx-BEST1 is an emerging gene therapy administered through a one-time subretinal injection designed to restore function to the retinal pigment epithelium (RPE) cells affected by mutations in the BEST1 gene. The Phase 1/2 trial is being conducted by Dr. Mark Pennesi of the Retina Foundation of the Southwest and the Show less Read more
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