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Stock impact report

Karyopharm myeloma drug yields mixed data in myelofibrosis trial [Yahoo! Finance]

Karyopharm Therapeutics Inc. (KPTI) 
Last karyopharm therapeutics inc. earnings: 2/13 07:00 am Check Earnings Report
US:NASDAQ Investor Relations: investors.karyopharm.com/investor-relations
Company Research Source: Yahoo! Finance
Dive Brief: Karyopharm Therapeutics' multiple myeloma drug Xpovio helped people with the blood disorder myelofibrosis on a key measure of health, but didn't help reduce their symptoms when combined with the approved drug Jakafi in a Phase 3 trial, the company said Tuesday The company said it plans to discuss the data with the Food and Drug Administration, aiming to seek an extended approval for Xpovio, its only marketed drug and source of revenue. Approval in myelofibrosis could be “transformative” for Karyopharm by tripling Xpovio revenue, which stood at $115 million in 2025 , RBC Capital Markets analyst Brian Abrahams wrote in a note to clients. Following release of the data, Karyopharm announced it is raising $30 million from a private placement with healthcare investment firm RA Capital. Shares fell as much as 15% in Tuesday morning trading. Dive Insight: Myelofibrosis stems from bone marrow scarring that impedes the body's ability to produce healthy blood cells. Sympto Show less Read more
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