D2M Biotherapeutics Announces First Patient Dosed in A Phase 1 Study Evaluating [Yahoo! Finance]
Laboratory Corporation of America Holdings (LH)
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Source: Yahoo! Finance
April 18, 2024 /PRNewswire/ -- D2M Biotherapeutics, Inc. (D2M), a clinical stage biotech company focused on developing innovative therapies in treating Immunological-Inflammatory diseases and cancers, today announced that the first patient had been dosed in a phase 1, open-label, dose escalation and expansion study of DM919, a novel monoclonal antibody targeting MICA/B to restore and promote anti-tumor response by T and natural killer (NK) cells for the treatment of advanced solid tumors. This phase 1, first-in-human, multicenter, dose-escalation and expansion trial (NCT06328673) will evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and clinical activity of DM919 alone and in combination with anti-PD1 therapy in patients with advanced or metastatic solid tumors. "The initiation of this clinical study represents a major milestone for D2M," said Nan Bing , MD., Ph.D., co-founder and CEO of D2M. "The MICA/B targeted therapy is a novel modality in cancer treatment
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