Volastra Therapeutics Announces First Patient Dosed in Phase Ib Clinical Trial of Sovilnesib [Yahoo! Finance]
Eli Lilly and Company (LLY)
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Source: Yahoo! Finance
NEW YORK, April 16, 2024 BUSINESS WIRE Volastra Therapeutics , a clinical-stage biotechnology company, today announced it has dosed the first patient in its Phase Ib clinical trial evaluating sovilnesib in patients with platinum-resistant or refractory high-grade serous ovarian cancer (HGSOC). This trial ( NCT06084416 ) is a randomized dose optimization study of once-daily oral sovilnesib at different dose levels to establish the recommended Phase 2 dose. Sovilnesib was granted Fast Track designation in this indication by the U.S. Food and Drug Administration (FDA) based on its initial clinical data as well as the high unmet need in this population. Volastra in-licensed sovilnesib (formerly AMG-650) from Amgen in February 2023. The company is also progressing its internally developed KIF18A inhibitor, VLS-1488, in an ongoing Phase 1 clinical trial ( NCT05902988 "Advancing our two chemically differentiated KIF18A inhibitors in parallel Phase 1 clinical trials presents the rare opp
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