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Herpes Virus Fluidizes Cell Nuclei to Multiply Faster [Yahoo! Finance]

MOLECULAR PHARMACOLGY USA (MLPH) 
Company Research Source: Yahoo! Finance
(PRNewsfoto/NYU Langone Health) (PRNewsfoto/NYU Langone Health) The research centers on how the nucleus of each human cell houses the genetic machinery used to copy DNA-encoded instructions when it divides and multiplies as part of growth. Viruses invade human cells and use their machinery to copy themselves, but the invasion can be hindered by the dense structure of the nucleus. Led by researchers at NYU Langone Health, the new study found that herpes simplex virus uses a protein called infected cell protein 4 (ICP4) to make the human nucleus more fluid-like, which in turn makes it easier for the virus to replicate itself. Publishing online March 5 in Molecular Cell, the work revealed that blocking the ability of ICP4 to fluidize the nuclear compartment caused a four-fold drop in the production rate of new viral copies. "The physical state of the nucleus is a fundamental barrier that a virus must overcome to multiply," says senior study author Liam Holt, PhD , a professor in t Show less Read more
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