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Stock impact report

MediciNova concludes subject enrolment in trial of MN-166 [Yahoo! Finance]

MediciNova, Inc. (MNOV) 
Last medicinova, inc. earnings: 4/23 04:20 pm Check Earnings Report
Company Research Source: Yahoo! Finance
The trial randomised 234 participants across two treatment arms at several clinical centres in Canada and the US. Recruitment is now closed. MN-166 is a small molecule orally administered, intended to modulate neuroinflammation and oxidative stress implicated in ALS progression. COMBAT-ALS is a double-blind, randomised, placebo-controlled study with a 12-month blinded phase followed by a six-month open-label extension. The primary efficacy endpoint is the Combined Assessment of Function and Survival (CAFS). Secondary endpoints include the ALS Functional Rating Scale Revised (ALSFRS-R), quality of life evaluations, and muscle strength as measured by hand-held dynamometry. Top-line results are anticipated by the end of next year. Previous studies of MN-166 showed a positive safety profile and indications of treatment response in preclinical models and Phase I/II and Phase II studies. The therapy holds fast track and orphan drug designations from the US Food and Drug Administr Show less Read more
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