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0.0477528089887641 0.0536150464093795 0.184782608695652 0.140693698094773 0.160234489496825 0.010991695163654 -0.0779189057156816 -0.0254030288226675
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Monopar Announces Promising Preclinical Data for its MNPR-101 Radiopharma Program Targeting Advanced Cancers [Yahoo! Finance]

Monopar Therapeutics Inc. (MNPR) 
Company Research Source: Yahoo! Finance
biopharmaceutical company focused on developing innovative treatments for cancer patients, today announced promising preclinical imaging and therapeutic efficacy data for its MNPR-101 radiopharmaceutical program. This novel first-in-class radiopharma program targets cancers expressing the urokinase plasminogen activator receptor (uPAR), which include a majority of all triple-negative breast, colorectal, and pancreatic cancers. MNPR-101 Conjugated to Imaging Radioisotope Maximizing the dose delivered to the tumor relative to normal tissue is of paramount importance in radiopharmaceutical therapy. Figure 1 below shows the before and after optimization of MNPR-101-Zr, Monopar's radiopharmaceutical imaging agent for advanced solid tumors expressing uPAR. Monopar's in-house radiopharmaceutical development team was able to significantly increase tumor uptake of MNPR-101-Zr while minimizing uptake in healthy tissue, as shown in this preclinical positron emission tomography (PET) sequenti Show less Read more
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