NovaBridge Presents Positive Givastomig Dose Expansion Data from the Phase 1b Combination Study in Patients with 1L Metastatic Gastric Cancer
NovaBridge Biosciences - American Depositary Shares (NBP)
Company Research
Source: GlobeNewswire
Givastomig, a CLDN18.2 x 4-1BB bispecific antibody, continues to show robust efficacy when combined with nivolumab and chemotherapy (mFOLFOX6) in 1L HER2-negative, metastatic gastric cancer patients, with 77% ORR observed at 8 mg/kg and 73% ORR observed at 12 mg/kg, across a wide range of PD-L1 and CLDN18.2 expression levelsThe median PFS was 16.9 months at 8 mg/kg; 12 mg/kg is immature with approximately 4-month shorter median follow-up; data will be updated in 2026Six-month landmark PFS was 73% for 8 mg/kg, and 91% for 12 mg/kg cohortsCombination was well tolerated; safety is comparable to the current standard of care treatmentData demonstrate that givastomig is a potential best-in-class CLDN18.2 asset when added to 1L standard of careNovaBridge is on track to initiate enrollment in a global, randomized Phase 2 study, evaluating both doses against standard of care, in Q1 2026Detailed Phase 1b dose expansion data are expected to be presented at a medical conference later in 2026 ROC
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- NovaBridge Appoints Biotech Leader, Emmett T. Cunningham, Jr, MD, PhD, MPH, as Vice Chairman of the Board to Further Accelerate Global Biotech PlatformGlobeNewswire
- NovaBridge Doses First Patient in Global, Randomized Phase 2 Study of Givastomig Combined with Immunochemotherapy in Patients with 1L Metastatic Gastric CancerGlobeNewswire
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