NuCana Presents Encouraging Data on NUC-7738 in Combination with PD-1 Inhibitors using Primary Patient-Derived Organoids and Autologous Tumor-Infiltrating Lymphocytes at the ESMO Congress ...
NuCana plc - American Depositary Shares (NCNA)
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Source: Yahoo! Finance
BERLIN, Oct. 18, 2025 (GLOBE NEWSWIRE) -- NuCana plc (NASDAQ: NCNA) (“NuCana” or the “Company”) presented data at the European Society for Medical Oncology Congress 2025 (“ESMO”) on a new model system investigating the synergistic effects of NUC-7738 and PD-1 inhibition in primary organoids derived from patients with renal cell carcinoma (“RCC”). Using patient-derived organoids (“PDOs”) from ten patients with RCC and autologous tumor-infiltrating lymphocytes (“TILs”), co-culture experiments reveal that NUC-7738 enhances the effectiveness of PD-1 inhibitors, resulting in increased tumor cell killing. This combinatorial approach may offer a new option for cancers that no longer respond to anti-PD-1 therapy by targeting multiple aspects of the tumor microenvironment through the disruption of RNA polyadenylation and subsequent changes in cancer cell gene expression. The data presented at ESMO reinforces the mechanism of action for NUC-7738 as observed in the ongoing Phase 1/2 NuTide:
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News
- NuCana Announces Grant of Composition-of-Matter Patent for NUC-7738 in ChinaGlobeNewswire
- NuCana Presents Encouraging Data on NUC-7738 in Combination with PD-1 Inhibitors using Primary Patient-Derived Organoids and Autologous Tumor-Infiltrating Lymphocytes at the ESMO Congress 2025GlobeNewswire
- NuCana Announces Encouraging Data for NUC-3373 in Combination with Anti-PD-1 TherapyGlobeNewswire
- DNA Synthesis Inhibitors Market Gains Momentum with Growing Adoption in Oncology and Virology | DelveInsightPR Newswire
- DNA Synthesis Inhibitors Market Gains Momentum with Growing Adoption in Oncology and Virology | DelveInsightPR Newswire
NCNA
Sec Filings
- 11/5/25 - Form 6-K
- 10/20/25 - Form 6-K
- 10/14/25 - Form 6-K
- NCNA's page on the SEC website