ImmunityBio Study Shows Positive T Cell and Antibody Immune Responses to its COVID-19 Vaccine Candidate that Targets Both Spike and Nucleocapsid Virus Proteins
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Source: Business Wire
Preclinical results show this next generation Adeno (hAd5) vaccine, which targets both spike (S) and nucleocapsid (N) SARS-CoV-2 proteins, generates CD4+ and CD8+ T-cell responses, both of which can form long-term immune memory.Inclusion of nucleocapsid in this vaccine construct potentially overcomes the risk of emerging mutations in spike, which might limit the efficacy of S-only vaccines.In the study, all of the mice (5 out of 5) generated robust CD4+ and CD8+ antigen-specific T cells to S and N proteins.Four out of five mice generated an S-specific antibody response, with evidence of Th1 dominance, and two of these mice demonstrated potent neutralizing antibodies.Previous clinical studies have shown that ImmunityBio’s second generation hAd5 vector platform generates an immune response in patients with pre-existing immunity to adenoviruses, suggesting that prior adenovirus exposure is not a limitation for this platform during initial vaccination or a booster. CULVER CITY, Calif.-
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