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0.000357717760686747 -0.00160972992309074 -0.00286174208549461 -0.00321945984618136 0.00250402432480774 0.000715435521373621 0.00218923269540331 0.00214630656412086
Stock impact report

Pegging The Value Of NKTR-214 At Zero [Seeking Alpha]

Nektar Therapeutics (NKTR) 
Last nektar therapeutics earnings: 2/27 04:15 pm Check Earnings Report
US:NASDAQ Investor Relations: ir.nektar.com/investor-relations
Company Research Source: Seeking Alpha
Summary Please see the accompanying Slide Deck . A full PDF version of this article is provided at the bottom of this article. Since mid-2017, Nektar Therapeutics' ( NKTR ) stock price has tripled based on the view that its flagship clinical-stage drug NKTR-214 is a promising treatment for cancer, particularly in combination with checkpoint inhibitors. NKTR-214 is a pegylated form of recombinant IL-2, a naturally occurring cytokine that was first discovered in 1976 and approved for treating cancer in 1992 . By binding with the IL2Rß? receptor, IL-2 stimulates proliferation of cytotoxic lymphocytes, which then attack cancer cells. However, IL-2 has a short half-life and also binds with the IL2Raß? receptor, which is thought to induce proliferation of immunosuppressive Treg cells. Nektar hypothesized that IL-2 could be improved by adding polyethylene glycol molecules to it (pegylating it) to extend the half-life and block interaction with IL2Raß?. Unfortunately, t Show less Read more
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