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-0.00108991825613077 -0.00108991825613077 0 0.00108991825613077 -0.00165667574931881 0.00490463215258855 0.0130790190735694 0.0152588555858311
Stock impact report

Intellia Stock Declines Around 55% in 3 Months: Here's Why [Yahoo! Finance]

Intellia Therapeutics, Inc. (NTLA) 
Last intellia therapeutics, inc. earnings: 2/27 07:30 am Check Earnings Report
US:NASDAQ Investor Relations: ir.intelliatx.com/investor-overview
Company Research Source: Yahoo! Finance
to nexiguran ziclumeran (nex-z), NTLA's lead pipeline candidate. It is being developed in collaboration with Regeneron Pharmaceuticals REGN for the treatment of ATTR amyloidosis with cardiomyopathy (ATTR-CM) and ATTR amyloidosis with polyneuropathy (ATTRv-PN). In October 2025, Intellia temporarily halted dosing and patient enrollment in its late-stage MAGNITUDE and MAGNITUDE-2 studies, which were evaluating nex-z, its lead gene-editing therapy, for treating two cardiovascular indications, ATTR-CM and ATTRv-PN, respectively. The studies were halted after a patient experienced grade 4 liver transaminase elevations and increased total bilirubin following dosing with nex-z and later died. This triggered a clinical hold from the FDA on the investigational new drug applications and raised widespread concerns about the safety and future of the program. With the formal clinical hold in place, Intellia has suspended its milestone guidance for nex-z and will provide an update once a reg Show less Read more
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