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0.000354512151888775 3.93902390987155E-05 0.000512073108283749 3.93902390988275E-05 0.00153621932485136 0.00460865797455386 0.00216646315043137 0.00267853625871512
Stock impact report

Arrowhead nets first commercial win as siRNA drug garners FDA approval [Yahoo! Finance]

Novartis AG (NVS) 
Last novartis ag earnings: 4/28 01:00 am Check Earnings Report
US:NYSE Investor Relations: novartis.com/investors
Company Research Source: Yahoo! Finance
the company's small interfering RNA (siRNA) medicine for the treatment of familial chylomicronemia syndrome (FCS). Redemplo (plozasiran) has been authorised as an adjunct to diet to reduce triglycerides in adults with FCS, a rare disease that disrupts the body's ability to break down fats in the bloodstream. Patients with FCS have triglyceride levels that can be “ten to 100 times higher than normal”, according to Arrowhead. Acute pancreatitis is the most serious complication of the disease, according to the Endocrine Society. Redemplo is an siRNA therapeutic designed to suppress the production of apoC-III, a protein produced in the liver that raises triglyceride levels by slowing their breakdown and clearance. The drug can be self-administered at home every three months. The FDA based its decision on results from the Phase III PALISADE study (NCT05089084). The PALISADE study met its primary endpoint and all key secondary endpoints, including demonstrating significant reduction Show less Read more
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