A Better Concept For mRNA Vaccines: Self-Amplification [Forbes]
Pfizer, Inc. (PFE)
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Source: Forbes
The limitations of the current Pfizer and Moderna vaccines include short lifetime, substantial cold chain requirements, and lack of mature B and T cell responses due to short-lived synthesized proteins. Two newly reported vaccines using a self-amplifying RNA technology may overcome these problems: GEMCOVAC-OM and ARCT-154. These two mRNA vaccines herald a new era of vaccination for coronaviruses. This article delves into the unique mechanisms of self-amplifying messenger RNA vaccines based on promising results from recent human trials. Traditional mRNA vaccines contain a linear RNA instruction with pseudouridine modified nucleotides. When the mRNA enters your cells, they produce a protein that, if properly administered, induces an immune response. Self-amplifying RNA vaccines contain an additional genetic material that encodes an enzyme called a "replicase." This replicase can create multiple copies of the original self-amplifying RNA strand based on a viral RNA carrier that expre
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PFE
Earnings
- 5/1/24 - Beat
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- 5/9/24 - Form S-8
- 5/8/24 - Form 10-Q
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- PFE's page on the SEC website