Pliant Therapeutics Announces First Patient Dosed in FORTIFY, the Phase 1b Indication Expansion Trial Evaluating PLN-101095 in Patients with ICI-Refractory Solid Tumors
Pliant Therapeutics, Inc. (PLRX)
Company Research
Source: GlobeNewswire
SOUTH SAN FRANCISCO, Calif., April 30, 2026 (GLOBE NEWSWIRE) -- Pliant Therapeutics (Nasdaq: PLRX) today announced the dosing of the first participant in the FORTIFY Phase 1b open-label indication expansion clinical trial of PLN-101095 in combination with pembrolizumab, in patients with immune checkpoint inhibitor (ICI)-refractory advanced or metastatic solid tumors. PLN-101095 is an oral, small molecule, dual selective inhibitor of the integrins avß8 and avß1. “We are pleased to announce this milestone for the FORTIFY trial and the expansion into solid tumor cohorts that we believe are supported by PLN-101095’s mechanism of action,” said Bernard Coulie, M.D., Ph.D.., Chief Executive Officer of Pliant. “As a leader in integrin drug development, we look forward to exploring the full potential of this novel drug candidate.” FORTIFY - Phase 1b Clinical Trial Design The primary objective of this trial is to evaluate the safety, tolerability, pharmacokinetics and preliminary evidence
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News
- Pliant Therapeutics Announces Presentation of Updated Data from the Phase 1 Trial of PLN-101095 in Patients with ICI-Refractory Solid Tumors at the 2026 AACR Annual Meeting [Yahoo! Finance]Yahoo! Finance
- Pliant Therapeutics Announces Presentation of Updated Data from the Phase 1 Trial of PLN-101095 in Patients with ICI-Refractory Solid Tumors at the 2026 AACR Annual MeetingGlobeNewswire
- Pliant Therapeutics Announces Upcoming Presentation of Phase 1 Clinical Trial of PLN-101095 in Patients with Solid Tumors at the 2026 AACR Annual Meeting [Yahoo! Finance]Yahoo! Finance
- Pliant Therapeutics Announces Upcoming Presentation of Phase 1 Clinical Trial of PLN-101095 in Patients with Solid Tumors at the 2026 AACR Annual MeetingGlobeNewswire
- Pliant Therapeutics (PLRX) had its price target lowered by Canaccord Genuity Group Inc. from $4.00 to $3.00. They now have a "hold" rating on the stock.MarketBeat
PLRX
Earnings
- 3/11/26 - Beat
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Analyst Actions
- 3/13/26 - Canaccord Genuity
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Sec Filings
- 4/22/26 - Form ARS
- 4/22/26 - Form DEF
- 4/22/26 - Form DEFA14A
- PLRX's page on the SEC website