Polyrizon Announces Promising Permeation Kinetics Supporting Advancement of Its Intranasal Naloxone Hydrogel Program
Polyrizon Ltd. - Ordinary Shares (PLRZ)
Company Research
Source: GlobeNewswire
Ra’anana, Israel, Dec. 11, 2025 (GLOBE NEWSWIRE) -- Polyrizon Ltd. (Nasdaq: PLRZ) (“Polyrizon” or the “Company”), a biotechnology company focusing on the development of intranasal products, today announced new results from its ongoing preclinical evaluation of its proprietary intranasal naloxone hydrogel formulation, demonstrating promising permeation kinetics that complement the Company’s previously reported stability and mucoadhesion successes. Following the positive mucoadhesion findings-where Polyrizon’s formulation showed significantly enhanced persistence on ex-vivo nasal tissue compared to a marketed intranasal naloxone product (p Importantly, despite the improved mucoadhesion demonstrated by Polyrizon’s formulation, permeation profiles remained rapid, with no statistically significant differences in permeation kinetics when compared to the marketed naloxone product. This indicates that the hydrogel’s enhanced residence time on the nasal mucosa does not impede or delay dr
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News
- Polyrizon Submits Pre-Request for Designation to FDA for PL-16 Viral Blocker Designed to Reduce the Exposure to Influenza and Cold Viruses [Yahoo! Finance]Yahoo! Finance
- Polyrizon Submits Pre-Request for Designation to FDA for PL-16 Viral Blocker Designed to Reduce the Exposure to Influenza and Cold VirusesGlobeNewswire
- Polyrizon Completes FDA Pre-Submission Meeting for PL-14 Allergy Blocker Nasal SprayGlobeNewswire
- From Lab to Global Impact: Polyrizon's Journey to Potentially Redefining Next-Generation Nasal ProtectionGlobeNewswire
- Polyrizon Reports Positive Mucoadhesion Results for Intranasal Naloxone Hydrogel Compared to Marketed Intranasal Naloxone product [Yahoo! Finance]Yahoo! Finance
PLRZ
Sec Filings
- 12/19/25 - Form 6-K
- 12/12/25 - Form SCHEDULE
- 12/12/25 - Form SCHEDULE
- PLRZ's page on the SEC website