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0 0 0.00423728813559322 0.00398305084745762 0.0142372881355933 0.0132203389830509 -0.00398305084745762 -0.0105932203389831
Stock impact report

Praxis (PRAX) Surges on Positive Epilepsy Study Results [Yahoo! Finance]

Praxis Precision Medicines, Inc. (PRAX) 
Company Research Source: Yahoo! Finance
mid-stage study evaluating PRAX-628 in epilepsy patients with photo paroxysmal response (PPR). PRAX-628 is a next-generation, functionally selective small molecule targeting the hyperexcitable state of sodium channels in the brain. It is currently being developed as a once-daily oral treatment for adult focal onset epilepsy. PPR studies measure electroencephalogram signatures after intermittent photic stimulation and are used as an indicator of anti-seizure efficacy. Two doses were evaluated in the phase IIa proof of concept study. A total of six patients were baselined in the 15 mg cohort, of whom five were evaluable. One patient in the 15 mg cohort did not present adequate PPR at the baseline to be evaluated. Four patients were baselined in the 45 mg cohort, of whom three were evaluable. One patient in the 45 mg cohort was not evaluable due to lack of eligibility. Three patients from the 15mg cohort participated in the 45mg cohort after a washout period of greater than 100 day Show less Read more
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