Protagonist Therapeutics Initiates Phase 2 Study of Novel Hepcidin Mimetic PTG-300 in the Treatment of Patients with Polycythemia Vera
Protagonist Therapeutics, Inc. (PTGX)
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Source: PR Newswire
NEWARK, Calif., Oct. 30, 2019 /PRNewswire/ -- Protagonist Therapeutics, Inc. (Nasdaq:PTGX) today announced that the first patient has been dosed in a Phase 2 study of PTG-300 in patients with polycythemia vera (PV), a myeloproliferative disorder characterized by overproduction of red blood cells."In addition to our ongoing study of PTG-300 in patients with beta-thalassemia, we are excited to expand its clinical development with the initiation of this proof-of-concept study in polycythemia vera," commented Dinesh V. Patel, Ph.D., Protagonist President and Chief Executive Officer. "An important aspect of the mechanism of action of the hepcidin mimetic PTG-300 is to reduce iron availability, which is required to support the excessive erythropoiesis which occurs in PV, thereby potentially enabling PTG-300 to manage this excessive erythropoiesis and ultimately reduce the phlebotomy burden in these patients."The Phase 2 study of PTG-300 in PV is designed to monitor the safety profile and to
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