RedHill Biopharma's Positive Opaganib Results Indicate Reduction in Venetoclax Resistant Cells [Yahoo! Finance]
Redhill Biopharma Ltd. - American Depositary Shares (RDHL)
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Source: Yahoo! Finance
emerging as a therapeutic challenge, with leukemic cells persisting over time, even with combination therapy Studies show that sphingosine kinase 2 (SPHK2) is overexpressed in venetoclax-resistant cancer cells and that SPHK2 inhibition may reduce T-cell-induced activation and proliferation of venetoclax-resistant CLL cancer cells and resensitize previously resistant CLL cells New in vivo study shows adding opaganib, a potent SPHK2 inhibitor, to venetoclax reduces CLL cell (CD19?, CD5?) counts by 50% compared to controls and lowered CD3 , CD4 and CD8 T cell counts compared to controls with lowered PD1 expression (CD8 Data shows opaganib's venetoclax combination potential in CLL; builds on multiple preclinical studies demonstrating opaganib's therapeutic add-on potential in oncology; further clinical evaluation ongoing in a Phase 2 study of opaganib + darolutamide in advanced prostate cancer Opaganib has a safety and tolerability profile shown in more than 470 clinical trials /
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News
- RedHill Biopharma's Positive Opaganib Results Indicate Reduction in Venetoclax Resistant CellsPR Newswire
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