Dupixent® (dupilumab) Showed Positive Topline Results in Two Phase 3 Trials of Patients with Chronic Rhinosinusitis with Nasal Polyps
Regeneron Pharmaceuticals, Inc. (REGN)
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Source: PR Newswire
TARRYTOWN, N.Y. and PARIS, Oct. 16, 2018 /PRNewswire/ -- Dupixent significantly reduced nasal polyp size, nasal congestion severity and need for systemic corticosteroids and/or surgeryDupixent has now demonstrated positive late-stage results in three Type 2 or allergic inflammatory diseases: atopic dermatitis, asthma and chronic rhinosinusitis with nasal polypsRegeneron Pharmaceuticals, Inc. (NASDAQ: REGN) and Sanofi today announced that both pivotal Phase 3 placebo-controlled trials evaluating Dupixent® (dupilumab) in adults with inadequately-controlled chronic rhinosinusitis with nasal polyps ("CRSwNP"), met all their primary and secondary endpoints. On the co-primary endpoints for both trials at 24 weeks, patients treated with Dupixent added to a standard-of-care corticosteroid nasal spray experienced a 51% and 57% improvement in their nasal congestion/obstruction severity compared to a 15% and 19% improvement with nasal spray alone ("placebo") (-1.25 and -1.34 for Dupixent compare
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