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Regulus Therapeutics Advances to Cohort 4 of Phase 1b Multiple-Ascending Dose (MAD) Clinical Trial of RGLS8429 for the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD) [Ya...

Regulus Therapeutics Inc. (RGLS) 
Last regulus therapeutics inc. earnings: 3/12 04:37 pm Check Earnings Report
US:NASDAQ Investor Relations: regulusrx.com/investors
Company Research Source: Yahoo! Finance
of innovative medicines targeting microRNAs (the "Company" or "Regulus"), today announced, after review of all available safety data, the Company initiated screening in the of the fourth cohort of patients in the Phase 1b MAD study of RGSL8429 for the treatment of ADPKD. Patients in the fourth cohort will receive an open label fixed dose of 300 mg of RGLS8429 every other week for three months. The study protocol has been amended to include up to 30 subjects in the fourth cohort in order to further examine potential impact on total kidney volume in patients with APDKD. "After sharing positive topline data from cohort 2 that further validates RGLS8429's potential efficacy in ADPKD, we are moving to the fourth and final cohort of the Phase 1b MAD study," said Jay Hagan , CEO of Regulus Therapeutics. "This open label, fixed dose cohort will provide essential insight and data as we begin to think about study design for our potentially pivotal Phase 2 trial. Our team is looking forward to Show less Read more
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