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0.104427333974976 0.0721847930702599 0.0813282001924927 0.106833493743985 0.106833493743985 0.142925890279114 0.174205967276227 0.168912415784408
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Priovant Announces Positive Phase 2 Results for Brepocitinib in Cutaneous Sarcoidosis (CS)

Roivant Sciences Ltd. (ROIV) 
Company Research Source: GlobeNewswire
Brepocitinib 45 mg significantly improved cutaneous sarcoidosis disease activity, achieving a 22.3-point improvement in mean CSAMI-A at Week 16 versus a 0.7-point improvement in placebo (? 21.6 PAll brepocitinib 45 mg patients achieved a clinically meaningful response, with 100% demonstrating at least a 10-point improvement on CSAMI-AOn the Investigator’s Global Assessment (IGA), 69% percent of brepocitinib 45 mg patients compared to 0% of placebo patients achieved the gold standard two-point improvement to “Clear” (0) or “Almost Clear” (1) (? 69% P=.0047)Brepocitinib 15 mg patients also improved considerably, with numerically similar improvement to the 45 mg arm on lower-bar endpoints and evidence of dose-dependent benefit seen on higher bar endpoints and patient reported outcomesBrepocitinib was well tolerated during the study treatment period, with no Serious Adverse Events (SAEs) and all Adverse Events (AEs) graded mild or moderate in severityPriovant plans to progress CS to a piv Show less Read more
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