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Stock impact report

AbbVie buyout Cerevel posts late-stage win for Parkinson's disease drug [Seeking Alpha]

Reviva Pharmaceuticals Holdings, Inc. (RVPH) 
Company Research Source: Seeking Alpha
candidate, tavapadon, reached its main goals in a pivotal Phase 3 trial as a combination therapy. The TEMPO-3 study for adults with advanced PD succeeded as tavapadon in combination with brain therapy levodopa indicated a clinically meaningful and statistically significant difference compared to placebo in terms of the primary endpoint, the company said. The 27-week study for 507 patients considered the change from baseline in the total “on” time without troublesome dyskinesia as the primary endpoint, which showed an increase of 1.1 hours in the on-drug arm compared to the placebo arm (1.7 hours vs. 0.6 hours). Compared to the placebo group, there was a statistically significant reduction in “off” time, the key secondary endpoint in the tavapadon plus levodopa arm. Regarding safety, the company added that the study drug was well-tolerated, with most of the adverse events being mild to moderate in severity. Cerevel ( CERE ) expects to use the findings to support future regula Show less Read more
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