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Stock impact report

Recursion Pharmaceuticals Rises as Positive Phase 1b/2 Trial Results for REC-4881 Validate AI-Driven Drug Discovery Platform [Yahoo! Finance]

Recursion Pharmaceuticals, Inc. - Class A (RXRX) 
Company Research Source: Yahoo! Finance
positive Phase 1b/2 results for REC-4881, which is its investigational allosteric MEK1/2 inhibitor designed to treat Familial Adenomatous Polyposis/FAP. FAP is a rare, life-altering hereditary condition affecting over 50,000 people in the US and EU5. It is driven by inactivating mutations in the APC gene, which typically result in a near-100% lifetime risk of colorectal cancer. Currently, no medical therapies are approved, forcing patients to undergo frequent endoscopic removals and major surgeries, such as colectomies, starting in their early 20s. The TUPELO trial data demonstrated that REC-4881 achieved both rapid and durable clinical activity. The study revealed that 87% of untreated individuals experience a progressive increase in polyp burden, with only 3% showing any modest decrease. The safety profile of REC-4881 remained consistent with the MEK1/2 inhibitor class; most treatment-related adverse events were mild (Grade 1 or 2), such as acneiform dermatitis or elevated blood Show less Read more
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