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Sana Biotechnology Showcases Successful In Vivo Gene Editing of Stem Cells in Nature Publication [Yahoo! Finance]

Sana Biotechnology, Inc. (SANA) 
Company Research Source: Yahoo! Finance
the publication of groundbreaking preclinical data in the journal Nature Biotechnology. The study, titled “In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles,” details the successful use of Sana's Fusogen platform to perform gene editing directly within the body. Using systemic delivery in murine models, the company showed that its virus-like particles/VLPs could precisely target and edit hematopoietic stem cells/HSCs inside the bone marrow, achieving stable results in long-term HSCs. The publication highlights the versatility of the Fusogen technology, which has now proven capable of delivering diverse payloads (including CRISPR gene-editing and base-editing machinery) to two distinct cell types: T cells and HSCs. A critical finding of the study was the platform's high specificity; the targeted particles successfully avoided off-target delivery to other organs, such as the liver (hepatocytes) or gonadal tissues. By Show less Read more
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