Septerna Announces Positive Phase 1 Data for SEP-631, an Oral MRGPRX2 NAM for the Treatment of Mast Cell-Driven Diseases, and Outlines Initial Phase 2 Development Strategy
Septerna, Inc. (SEPN)
Company Research
Source: GlobeNewswire
SEP-631 Demonstrated Robust, Dose-Dependent Inhibition of Icatibant-Induced Skin Wheal Formation, with Complete Inhibition Observed at Doses as Low as 10 mg Once-Daily Well-Tolerated Across All Doses Studied with an Adverse Event Profile Comparable to Placebo; Pharmacokinetic Profile Supports Once-Daily Oral Dosing Phase 2 Development Planned to Begin with Chronic Spontaneous Urticaria in the Second Half of 2026 Company to Host Conference Call and Webcast on Monday, March 2, 2026, at 8:00 a.m. ET SOUTH SAN FRANCISCO, Calif., March 01, 2026 (GLOBE NEWSWIRE) -- Septerna, Inc. (Nasdaq: SEPN), a clinical-stage biotechnology company pioneering oral small molecule GPCR-targeted medicines, today announced positive results from its Phase 1 clinical trial evaluating SEP-631, a potent and selective oral negative allosteric modulator (NAM) of Mas-related G protein-coupled receptor X2 (MRGPRX2). Based on these results, Septerna plans to advance SEP-631 into Phase 2 development for chroni
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SEPN
News
- Septerna (SEPN) had its price target raised by Wells Fargo & Company from $28.00 to $48.00. They now have an "overweight" rating on the stock.MarketBeat
- Septerna (SEPN) had its price target raised by HC Wainwright from $35.00 to $40.00. They now have a "buy" rating on the stock.MarketBeat
- Septerna Announces Positive Phase 1 Data for SEP-631, an Oral MRGPRX2 NAM for the Treatment of Mast Cell-Driven Diseases, and Outlines Initial Phase 2 Development Strategy [Yahoo! Finance]Yahoo! Finance
- Septerna (SEPN) was upgraded by Zacks Research from "strong sell" to "hold".MarketBeat
- Septerna to Present at TD Cowen 46th Annual Health Care ConferenceGlobeNewswire
SEPN
Sec Filings
- 3/4/26 - Form 4
- 3/2/26 - Form 144
- 3/2/26 - Form 8-K
- SEPN's page on the SEC website