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-0.00116009280742457 -0.00269141531322517 -0.0150812064965198 0.00464037122969828 -0.00464037122969848 0.021461716937355 -0.0562529002320185 -0.0510440835266821
Stock impact report

Sagimet Biosciences Shares Jump 30% on Acne Trial Expansion Plans [Yahoo! Finance]

Sagimet Biosciences Inc. (SGMT) 
Company Research Source: Yahoo! Finance
clinical trial of denifanstat for moderate to severe acne in the U.S. during the second half of 2026. The clinical-stage biopharmaceutical company said it is advancing denifanstat into the U.S. acne market, supported by recently reported positive Phase 3 data from China. The upcoming trial will depend on Investigational New Drug clearance, with the company aiming to submit its IND application by mid-2026. Denifanstat Targets Key Drivers of Acne Sagimet explained that denifanstat works by inhibiting fatty acid synthase, helping to lower sebum production while also addressing localized inflammation associated with acne vulgaris. The condition impacts roughly 10 million people annually in the U.S. If approved, the company said denifanstat would be a once-daily oral therapy and the first new oral acne treatment in more than four decades. Positive China Trial Data Supports U.S. Strategy In January 2026, Sagimet's partner Ascletis Bioscience Co. Ltd. reported encouraging topline Show less Read more
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