Tolero Pharmaceuticals Announces First Patient Dosed in Phase 1 Study of Investigational Agent TP-3654 in Patients with Advanced Solid Tumors
SUMITOMO CHEM UNSP/ADR (SOMMY)
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Source: PR Newswire
SALT LAKE CITY, May 14, 2019 /PRNewswire/ -- Tolero Pharmaceuticals, Inc., a clinical-stage company focused on developing novel therapeutics for hematological and oncological diseases, today announced the first patient has been dosed in a Phase 1 study evaluating the investigational agent TP-3654, a PIM kinase inhibitor, in patients with advanced solid tumors. The open-label, dose-escalation, safety, pharmacokinetics, and pharmacodynamic study will evaluate the dose-limiting toxicities and clinical activity of oral TP-3654 administered in patients with advanced solid tumors. "TP-3654 is a second generation PIM inhibitor and is an important compound within our pipeline of multiple oncology assets being developed in various solid and liquid tumors," said David J. Bearss, CEO of Tolero. "By targeting PIM kinases, which are key signaling mediators downstream of several cytokines, we are hopeful that TP-3654 may provide an opportunity to not only target cancer cells but also alter the tumo
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