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Scholar Rock Announces Publication in Science Translational Medicine of Preclinical Data Detailing a Potent and Selective Inhibitor of TGFß1 Overcoming Primary Resistance to Checkpoint Inh...

Scholar Rock Holding Corporation (SRRK) 
Last scholar rock holding corporation earnings: 11/12 07:30 am Check Earnings Report
Company Research Source: Business Wire
- Retrospective analyses of clinical tumor samples identify TGFß1 as the most prevalent TGFß isoform in most solid cancers- Preclinical results demonstrate highly selective inhibition of TGFß1 activation with SRK-181-mIgG1 overcomes key mechanism of primary resistance to checkpoint inhibition therapy- Selective inhibition of latent TGFß1 activation with SRK-181 has demonstrated an improved preclinical safety profile compared to conventional inhibitors of TGFß signaling CAMBRIDGE, Mass.--(BUSINESS WIRE)--Scholar Rock (NASDAQ: SRRK), a clinical-stage biopharmaceutical company focused on the treatment of serious diseases in which protein growth factors play a fundamental role, today announced the publication in the peer-reviewed journal Science Translational Medicine of preclinical data that established the therapeutic rationale for evaluating a potent and highly selective inhibitor of transforming growth factor-beta 1 (TGFß1) activation to overcome primary resistance to checkpoint in Show less Read more
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