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Stock impact report

Theravance Stock Declines Around 17% in Three Months: Here's Why [Yahoo! Finance]

Theravance Biopharma, Inc. - Ordinary Shares (TBPH) 
Last theravance biopharma, inc. - ordinary shares earnings: 2/24 04:05 pm Check Earnings Report
US:NASDAQ Investor Relations: investor.theravance.com/investor-relations
Company Research Source: Yahoo! Finance
follows a major setback involving its lead pipeline candidate, ampreloxetine, a once-daily norepinephrine reuptake inhibitor. Failure of Phase III CYPRESS Study Weighs on TBPH In March 2026, Theravance announced top-line data from the pivotal phase III CYPRESS study, which evaluated ampreloxetine for the treatment of symptomatic neurogenic orthostatic hypotension in patients with multiple system atrophy, a progressive neurological disorder. The study failed to meet its primary endpoint in the Orthostatic Hypotension Symptom Assessment composite score. Secondary endpoints were not statistically significant, despite showing biological activity. Consequently, TBPH decided to wind down the ampreloxetine program entirely. This significantly weakened its pipeline outlook and reduced long-term revenue potential. Following the setback, Theravance's strategic review committee is accelerating its evaluation of strategic options, including a potential sale of the company, to maximize sha Show less Read more
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