Tiziana Announces Data Showing Nasal Anti-CD3 Improves Cognition Associated with Aging
Tiziana Life Sciences Ltd - Common Shares (TLSA)
Company Research
Source: GlobeNewswire
BOSTON, April 01, 2026 (GLOBE NEWSWIRE) -- Tiziana Life Sciences, Ltd. (Nasdaq: TLSA) (“Tiziana”), a biotechnology company developing its lead candidate, intranasal foralumab, a fully human, anti-CD3 monoclonal antibody, announces positive preclinical data highlighting nasal anti-CD3’s potential as a novel approach to address neuroinflammation associated with aging, which contributes to cognitive decline in age-related disorders. In the study, nasal anti-CD3 reversed key aspects of brain aging, and improved cognition. Key study findings: Nasal anti-CD3 dampens microglial activation that drives chronic neuroinflammation. This reduction in inflammation, which is strongly linked to cognitive decline, suggests the therapy could help mitigate the inflammatory burden and slow aspects of the aging process.Nasal anti-CD3 enhances neurogenesis in the hippocampus, a region critical for learning and memory and reduces cellular senescence by down regulating inflammatory markers and age-relate
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News
- Tiziana says intranasal drug shows potential to ease Long COVID “brain fog” [Yahoo! Finance]Yahoo! Finance
- Tiziana Life Sciences Announces Publication of Positive Data Demonstrating Intranasal Anti-CD3 Antibody Attenuates Long COVID Neuroinflammation and Improves Cognitive FunctionGlobeNewswire
- Tiziana Life Sciences Announces Late Breaking Poster Accepted for Presentation at the 7th World Parkinson CongressGlobeNewswire
- Tiziana Reports Promising Data Showing Nasal Anti-CD3 May Improve Age-Related Cognitive Decline [TheStreet.com]TheStreet.com
- Tiziana Life Sciences Announces New Biomarker Data Showing Nasal Foralumab Downregulates CSF Inflammation, Upregulates Neuroprotective Pathways, and Correlates with Reduced Microglial Activation on PET Scans in na-SPMS Patients with PIRAGlobeNewswire
TLSA
Sec Filings
- 4/16/26 - Form 6-K
- 4/14/26 - Form 6-K
- 4/1/26 - Form 6-K
- TLSA's page on the SEC website